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What is Acomplia?

Acomplia (Rimonabant) is the first in a new class of therapeutic agents called Cannabinoid-1 Receptor Blockers (CB1).
Acomplia is used in the treatment of obesity and related conditions.

How does Acomplia work?

Acomplia acts by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid (or fat) metabolism, including adipose tissue, the liver, gastrointestinal tract and muscle1.
Acomplia switches off the same brain circuits that make people hungry when they smoke cannabis.
CB1 receptor blockade with Acomplia acts to decrease the overactivity of the endocannabinoid system (EC system)2,3. The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor and it has been shown to play an important role in regulating body weight and in controlling energy balance, as well as glucose and lipid (or fat) metabolism.

What is Acomplia used for?

Acomplia is used complementary to diet and exercise to treat obese or overweight patients who suffer from Type 2 diabetes and abnormal levels of fat in the blood.
Sanofi argues that Acomplia can also prevent the risk of cardiovascular disease.
Patients with large waist circumference (102 cm in men and 88 cm in women) will mostly benefit from taking the drug.

Does Acomplia also aid smoking cessation?

Acomplia has been studied by sanofi-aventis as an aid to smoking cessation based on studies for up to one year in over 6,500 smokers motivated to quit smoking.
Sanofi-aventis submitted a New Drug Application to the FDA, which in turn issued a non approvable letter for Acomplia for use in smoking cessation. An approvable letter was however issued for Acomplia for use in weight management.

Acomplia has just been approved in the European Union. Is Acomplia approved in the United States?

No. Sanofi is still awaiting U.S. marketing go-ahead which it has said could come by the end of this year.
U.S. health authorities have asked Sanofi for more information on Acomplia.
Acomplia received European Union marketing approval in June 2006.
The first launch will take place in Britain in July and be followed by launches in Denmark, Ireland, Germany, Finland and Norway in the second half of this year, according to Sanofi.

What were the results of Acomplia Clinical trial studies?

In clinical studies, Acomplia has been shown to improve a wide array of cardiometabolic risk factors as well as promoting sustained weight loss4,5.
Approximately half of the observed improvement in HDL-cholesterol, triglycerides and HbA1C (an indicator of blood sugar control) in patients who received Acomplia 20mg was beyond that expected from weight loss alone.

What are the side-effects of Acomplia?

Side effects in the trial on Acomplia in obesity were vomiting and nausea, forcing about 19 percent of patients to leave the trial versus 13 percent of those who took placebo.

What is the shelf life of the pills?

The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.

The hormonal connection: insulin resistance - why moderate changes to the protein/carbohydrate ratio work
Commenting on why moderate changes to the protein/carbohydrate ratio work, nutritionist Crayhon states, "Protein helps support the endocrine system nicely, particularly the adrenal glands' ability to support blood sugar. And protein goes to the liver to participate in a process called gluconeogenesis, in which protein is turned into blood sugar slowly, keeping blood sugar levels stable so cravings decrease. Hypoglycemia is helped too. This is the kind of eating program that helps people lose weight, feel more energetic, have no cravings. And it's so easy."
Simple carbohydrates, found in refined foods such as alcohol, white flour, and white rice, wreak havoc on blood sugar and should be avoided by the carbohydrate-sensitive person at all cost. Because these foods lack fiber, the body quickly converts them to sugar, causing blood glucose levels to rise rapidly. As mentioned earlier, complex carbohydrates burn more slowly and, for the most part, are better tolerated. But you should note that certain complex carbohydrates have been found to increase blood sugar faster than others. The rate at which blood sugar levels rise after a specific food is eaten is called its glycemic index. The potato, in particular, is a high-glycemic-index food and should be consumed less frequently than beans, legumes, and brown rice, which are low-glycemic-index choices.

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